RANK: Large-Scale Inference with Graphical Nonlinear Knockoffs

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• Yingying Fan (University of Southern California)
• Tuesday 16 January 2018, 11:00-11:45
• Seminar Room 1, Newton Institute.

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STSW01 - Theoretical and algorithmic underpinnings of Big Data

Co-authors: Emre Demirkaya (University of Southern Califnornia), Gaorong Li (Beijing University of Technology), Jinchi Lv (University of Southern Califnornia)

Power and reproducibility are key to enabling refined scientific discoveries in contemporary big data applications with general high-dimensional nonlinear models. In this paper, we provide theoretical foundations on the power and robustness for the model- free knockoffs procedure introduced recently in Cand`es, Fan, Janson and Lv (2016) in high-dimensional setting when the covariate distribution is characterized by Gaussian graphical model. We establish that under mild regularity conditions, the power of the oracle knockoffs procedure with known covariate distribution in high-dimensional linear models is asymptotically one as sample size goes to infinity. When moving away from the ideal case, we suggest the modified model-free knockoffs method called graphical nonlinear knockoffs (RANK) to accommodate the unknown covariate distribution. We provide theoretical justifications on the robustness of our modified procedure by showing that the false discovery rate (FDR) is asymptoti cally controlled at the target level and the power is asymptotically one with the estimated covariate distribution. To the best of our knowledge, this is the first formal theoretical result on the power for the knock- offs procedure. Simulation results demonstrate that compared to existing approaches, our method performs competitively in both FDR control and power. A real data set is analyzed to further assess the performance of the suggested knockoffs procedure.

Related Links

• fanyingy%2Fpublications%2FRANK-FDLL17.pdf">http://www-bcf.usc.edu/fanyingy/publications/RANK-FDLL17.pdf

This talk is part of the Isaac Newton Institute Seminar Series series.

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