Functional Genomics to Study Cancer

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• David Sabatini, Whitehead Institute
• Thursday 28 June 2018, 13:00-14:00
• CRUK CI Lecture Theatre.

If you have a question about this talk, please contact Kate Davenport.

We are using genome-scale CRISPR -Cas9 genetic screens in a large number of human cancer cell lines to study cancer. With this approach we are defining oncogenic drivers, synthetic lethal interactions, and genes that modulate the response to drug therapies. I will discuss the big picture lessons we have learned as well as the challenges we have encountered. I will also present efforts to develop tissue culture media that better mimics the metabolic composition of human plasma and our efforts to understand how the metabolic milieu affects the genetic dependencies of cancer cells.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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