Reprogramming the Genetic Code

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• Dr Jason Chin, Centre for Chemical & Synthetic Biology, MRC Laboratory of Molecular Biology
• Wednesday 18 May 2016, 16:00-17:00
• Wolfson Lecture Theatre, Department of Chemistry.

If you have a question about this talk, please contact Alice Wood.

The information for synthesizing the molecules that allow organisms to survive and replicate is encoded in genomic DNA . In the cell, DNA is copied to messenger RNA , and triplet codons (64) in the messenger RNA are decoded – in the process of translation – to synthesize polymers of the natural 20 amino acids. This process (DNA RNA protein) describes the central dogma of molecular biology and is conserved in terrestrial life.

We are interested in re-writing the central dogma to create organisms that synthesize proteins containing unnatural amino acids and polymers composed of monomer building blocks beyond the 20 natural amino acids. I will discuss our invention and synthetic evolution of new ‘orthogonal’ translational components (including ribosomes and aminoacyl-tRNA synthetases) to address the major challenges in re-writing the central dogma of biology. I will also discuss the application of the approaches we have developed for incorporating unnatural amino acids into proteins and investigating and synthetically controlling diverse biological processes, with a particular emphasis on understanding the role of post-translational modifications.

This talk is part of the Biological Chemistry Research Interest Group series.

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