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Discrete and continuous modelling of cell mechanics: from adhesion to migration

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Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation

The talk is devoted to two different approaches to model and simulate processes occurring during cell migration. Firstly, a discrete computational model in 3D is presented to simulate the formation of cell-matrix adhesions on a single 3D matrix fibre. This model allows to analyse the importance of the alignment between the matrix fibre and the cell protrusion on the size of the focal adhesions. Secondly, a 1D multi-physics model of fluid-structure interaction to simulate the behaviour of a cell confined in a complex microfluidics device is introduced. Cells are modelled as a poroelastic material following recent experimental evidences whereas the fluid is modelled by using the Poiseuille equation, considering it as a laminar incompressible Newtonian fluid.

This talk is part of the Isaac Newton Institute Seminar Series series.

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