Genetic screening of the human kinome identifies a cellular signalling network predictive of brain atrophy in Alzheimer's disease & Circadian abnormality in Alzheimer's disease: insights from animal models

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• Becky Inkster (Dept Psychiatry) & Ko-Fan Chen (Dept Genetics)
• Wednesday 15 April 2015, 18:30-20:00
• Gurdon Institute Tea Room.

If you have a question about this talk, please contact YS.

“Genetic screening of the human kinome identifies a cellular signalling network predictive of brain atrophy in Alzheimer’s disease” (Becky Inkster) Searching for gene variants that influence brain atrophy in Alzheimer’s disease is highly warranted; however, conventional genome-wide approaches have limited statistical power and fail to incorporate information about intrinsic biological relationships. The speaker will present new unpublished findings of a genetic network of kinases that putatively represent a set of functionally diverse genetic factors that relate to, and possibly predict, AD neurodegeneration.

“Circadian abnormality in Alzheimer’s disease: insights from animal models” (Ko-Fan Chen) Circadian abnormality, such as sleep fragmentation and disruption in rest/activity cycle, has been observed in various neurodegenerative disorders including Alzheimer’s disease (AD). The speaker will summarise circadian behavioural characteristics in AD and highlight the technical advances in measuring sleep and circadian behaviour in the related murine and fly models.

This talk is part of the "Life Sciences Masterclass" series.

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