Genome wide characterization of Foxa1/2 binding sites reveals multiple mechanisms for regulating neuronal specification and differentiation in midbrain dopamine cells.

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• Dr Emmanouil Metzakopian, Wellcome Trust Sanger Institute
• Wednesday 21 May 2014, 12:00-13:00
• Brain Repair Centre, Forvie Site, Robinson Way.

If you have a question about this talk, please contact Shannon Tinley-Browne.

The transcription factors Foxa1 and Foxa2 promote the specification of midbrain dopaminergic neurons. To better understand their functions, we characterized the Foxa1/2 cis-regulatory network by chromatin immunoprecipitation followed by high-throughput sequencing of dopamine neurons using in vitro and in vivo mouse models. The results highlight important mechanisms critical to midbrain dopamine neuron development.

This talk is part of the BRC Seminar Series series.

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