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Harnessing Genetic Dependencies in Cancer Therapy

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If you have a question about this talk, please contact Kate Davenport.

The design of targeted therapeutic strategies for cancer has largely been driven by the identification of tumor-specific genetic changes. However, the large number of genetic alterations present in tumor cells means that it is difficult to discriminate between genes that are critical for maintaining the disease state and those that are merely coincidental. Even when critical genes can be identified, directly targeting these is often challenging. We have exploited principles utilised for many years in model organisms to address these issues. Here I will describe particular examples of the use of synthetic lethality in cancer therapy. In addition, I will discuss high-throughput screening strategies to identify genetic dependencies in tumours.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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