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Molecular imaging of cancer: understanding chemotherapy response and resistance.

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If you have a question about this talk, please contact Leona Hope-Coles.

Molecular imaging allows us to visualise and quantify biological processes in intact living organisms, from cells, to mouse to man. In this talk, I will describe how molecular imaging is impacting clinical medicine, focusing on the detection and understanding of response to novel cancer therapeutics. Oxidative stress, an imbalance of free radicals and antioxidants, plays a key role in the initiation and progression of cancer. At present, our capabilities to observe and quantify redox processes in live cells and tissues are inadequate, hence our knowledge of the role of free radicals in normal cell signalling and how this is disrupted in malignant cells is limited.

My research aims to overcome this limitation by developing new, clinically translatable, molecular imaging tools to study the role of redox balance in cancer, specifically in the evolution of drug resistant disease. Recent developments in optical imaging technologies have led to the emergence of new contrast mechanisms that can be exploited for redox imaging, using new instruments and contrast agents. The ability to study redox processes noninvasively could provide unprecedented insight into the importance of redox biology in cancer progression, with clinical application in the areas of early cancer detection and cancer therapy. These tools will eventually enable studies of early lesion formation in cancer and other pathologies, including neurodegenerative disease.

This talk is part of the Special Departmental Seminars series.

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