Theoretical insights into co-translational folding: From pathways to proteomes

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• Dr Edward O'Brien
• Friday 04 November 2011, 12:00-13:00
• Unilever Lecture Theatre, Department of Chemistry.

If you have a question about this talk, please contact Dr Mark Miller.

Understanding protein folding in vivo and protein homeostasis in living cells requires we understand the concomitant folding of proteins during their biosynthesis by the ribosome molecular machine. I will discuss our efforts to understand the principles of such co-translational folding through the development of coarse-grained simulation force-fields, chemical kinetic modelling, and systems biology methods. These tools have allowed us to gain novel insights into fundamental issues in in vivo folding including the impact of variable translation rates, the effect of chaperones, and the co-translational folding properties of the E. coli proteome.

This talk is part of the Extra Theoretical Chemistry Seminars series.

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