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CATEGORIES:Extra Theoretical Chemistry Seminars
SUMMARY:Theoretical insights into co-translational folding
: From pathways to proteomes - Dr Edward O'Brien
DTSTART;TZID=Europe/London:20111104T120000
DTEND;TZID=Europe/London:20111104T130000
UID:TALK32397AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/32397
DESCRIPTION:Understanding protein folding in vivo and p
rotein homeostasis in living cells requires we und
erstand the concomitant folding of proteins during
their biosynthesis by the ribosome molecular mach
ine. I will discuss our efforts to understand the
principles of such co-translational folding throu
gh the development of coarse-grained simulation fo
rce-fields\, chemical kinetic modelling\, and syst
ems biology methods. These tools have allowed us t
o gain novel insights into fundamental issues in <
i>in vivo folding including the impact of vari
able translation rates\, the effect of chaperones\
, and the co-translational folding properties of t
he E. coli proteome.
LOCATION:Unilever Lecture Theatre\, Department of Chemistry
CONTACT:Dr Mark Miller
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