University of Cambridge > > Isaac Newton Institute Seminar Series > New methods of identifying fast-evolving sites in aligned sequence data

New methods of identifying fast-evolving sites in aligned sequence data

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If you have a question about this talk, please contact Mustapha Amrani.


Rate-heterogeneity across sites is a widely recognized problem in molecular phylogenetic studies. Attempts to overcome the problem involve deleting the fastest-evolving sites from the data before the phylogenetic analysis and/or using phylogenetic methods that assume rate-heterogeneity across sites can be modeled by a distribution of probabilities. Each of these methods has its advantages and limitations. Here, we describe and compare five metrics that may be used to identify the fast-evolving sites. One of these metrics (i.e., the probability of compatibility) turned out to be particular good at identifying fast-evolving sites, and when these sites are removed from the data, the result is an increase in the consistency of the alignment and, in some cases, another phylogeny.

This talk is part of the Isaac Newton Institute Seminar Series series.

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