'Mitochondrial release factors: a family or just good friends?'

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• Dr Zofia Chrzanowska-Lightowlers, University of Newcastel
• Wednesday 02 February 2011, 15:00-16:00
• Sackler Lecture Theatre (Level 7), Wellcome Trust/MRC Building, Addenbrooke's Site.

If you have a question about this talk, please contact Penny Peck.

Human mitochondria contain their own genome that is transcribed and all the mt-mRNAs so produced translated, within the organelle. There is a specific machinery required for intraorganellar protein synthesis that has similarities and differences to that of bacteria and the eukaryotic cytosol. The proteins that are involved in the termination step that facilitates release of the nascent peptide are of particular interest. These so called release factors (RF) need to be able to discriminate between sequences in the ribosomal A-site and recognize which are STOP codons. On interaction with the ribosome the RF changes conformation and facilitates hydrolysis of the ester bond that anchors the newly made protein to the final tRNA. Bioinformatic searches have now revealed a family of 4 predicted human mitochondrial release factors, with ICT1 and C12orf65 added to the previously described mtRF1 and mtRF1a. Intriguingly, these 2 new members, ICT1 and C12orf65, both lack the 2 regions involved in codon recognition and are therefore unlikely candidates for RNA triplet recognition.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• CamBridgeSens
• Cambridge talks
• Life Science Interface Seminars
• MRC Mitochondrial Biology Unit Seminars
• Sackler Lecture Theatre (Level 7), Wellcome Trust/MRC Building, Addenbrooke's Site
• Trust & Technology Initiative - interesting events

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