Diffusion in confining geometries: Counter-intuitive analytical results and supporting experiments with ion channels

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• Sergey M. Bezrukov, National Institutes of Health, Bethesda, MD, USA
• Tuesday 14 September 2010, 13:30-14:30
• Small Lecture Theatre, Cavendish Laboratory (**Note non-standard location**).

If you have a question about this talk, please contact Dr. Ulrich Keyser.

We explore the consequences of interactions between the pore and the translocating particles within the framework of a continuum diffusion model for the particle dynamics in the channel. Several of our findings are quite counter-intuitive (Biophys. J., 2005, 88:L17-L19; Phys. Rev. Lett., 2006, 97:020601; Phys. Rev. E, 2009, 80:020904®). Three of the examples to be discussed in the talk are: (i) “Sticking” to the channel slows down translocation (a particle spends more time in the channel) but increases the flux; (ii) “Uphill” and “downhill” particle translocation times (and their distributions) are identical; (iii) An optimal channel should exhibit the most pronounced binding on the side that is opposite to the side of the oncoming particles

This talk is part of the Physics of Medicine (PoM) Seminar Series series.

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