Remodelling the septin cytoskeleton for cytokinesis in budding yeast

Add to your list(s) Download to your calendar using vCal

• Dr Simonetta Piatti from Centre de Recherche en Biologie Cellulaire de Montpellier
• Thursday 12 March 2026, 14:00-15:00
• Biffen Lecture theatre and Zoom.

If you have a question about this talk, please contact Caroline Newnham.

Host - Marco Geymonat

Septins are conserved cytoskeletal proteins essential for processes such as cell division, spermatogenesis, neuronal morphogenesis, ciliogenesis, infection, and cell migration. Their dysfunction is linked to neurodegeneration, infertility, and cancer. Septins polymerize into filaments and higher-order structures like rings and arcs, which are crucial for their function. A classic example is the septin collar in budding yeast—an hourglass-shaped structure at the bud neck that persists through most of the cell cycle and is essential for cytokinesis. It recruits numerous cytokinetic proteins, including components of the contractile actomyosin ring. Just before cytokinesis, the yeast septin collar undergoes a major remodelling into a double ring that sandwiches the actomyosin ring. We recently showed that this remodelling is required for actomyosin ring constriction and successful cytokinesis. In this seminar, I will discuss our work uncovering the molecular basis of septin ring reorganisation in budding yeast. Interestingly, similar septin remodelling has been observed in other fungi and in mammalian cells, suggesting an evolutionarily conserved process.

This talk is part of the Genetics Seminar series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biffen Lecture theatre and Zoom
• Bioinformatics and other interests
• Biology
• CPB Maria
• Centre for Health Leadership and Enterprise
• DevBio
• Genetics Seminar
• Genetics Seminar Series
• Graduate-Seminars
• Life Sciences
• Life Sciences
• ME Seminar
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• PMRFPS's
• ji247's list
• my_list
• ndk22's list
• other talks

Note that ex-directory lists are not shown.