Lessons for human TB and its treatment from the tiny transparent zebrafish larva

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• Prof Lalita Ramakrishnan
• Tuesday 22 October 2024, 18:00-19:30
• Wolfson Lecture Theatre, Department of Chemistry, Lensfield Road.

If you have a question about this talk, please contact Zhang Xianghao Jeffrey.

Lalita Ramakrishnan is Professor of Immunology and Infectious Diseases at the University of Cambridge, Group Leader at the MRC Laboratory of Molecular Biology and Clinical Consultant in Infectious Diseases at Cambridge University Hospital. She decided to research TB three decades ago, motivated by the gravity of the disease – TB remains humanity’s greatest infectious – and the fascinating underlying biology. She pioneered the use of the transparent and genetically tractable zebrafish larva to study TB. This model organism has given important insights into how the TB bacteria cause disease and become tolerant to antibiotics. This work is translating into clinical studies and trials for human TB. Lalita will share how she got into the zebrafish along with stories of how it has helped to identify why certain people are more susceptible to TB, how the TB bacteria exploit these genetic vulnerabilities. Understanding these pathways has not only led to new drugs for TB but also revealed new fundamental biology. Lalita’s work has been recognized with many awards and honors. She is a Fellow of the Royal Society and a Member of the US National Academy of Sciences. She is the recipient of the 2024 Robert Koch award.

This talk is part of the SciSoc – Cambridge University Scientific Society series.

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