Leveraging AI for Breakthroughs in Genomic Research

Add to your list(s) Download to your calendar using vCal

• Mike Sikic, Genome Institute of Singapore
• Friday 24 May 2024, 12:00-13:00
• Lecture Theatre 2, Computer Laboratory, William Gates Building.

If you have a question about this talk, please contact Chaitanya's Talks List.

Hybrid: https://cam-ac-uk.zoom.us/j/2554325137?pwd=NGZEbGl1WkJxQVdkV09oc2k1L2pwQT09 Meeting ID: 255 432 5137 Passcode: 360730

This presentation will explore advancements in genomic research, starting with de novo assembly, where Šikić’s lab leads with novel applications of long reads technology. Herro, an innovative AI-based error correction model, increases the accuracy of simplex nanopore reads up to two orders of magnitude, starting a new era of genome sequencing with long and ultra reads whose accuracy exceeds 99.95 %. The talk will also introduce GNNOME , the lab’s pioneering GNN -driven de novo assembly tool, unlocking the potential to decode increasingly complex genomes across various ploidy and aneuploidy levels—a future lab goal.

In the second part, the talk will highlight the RNA 3D structure determination project. The lab has developed RiNALMo, the largest RNA language model with 650 million parameters. RiNALMo achieves previously unseen generalisation in downstream applications, such as secondary structure and splice site predictions.

Biography

Mile Šikić is the group leader at the Genome Institute of Singapore and a professor of computer science at the University of Zagreb, Croatia. Throughout his scientific career, he has specialized in developing algorithms and AI methods for genomics. His laboratory has created several cutting-edge tools, including the Racon consensus tool, the Raven de novo assembler, and the Edlib sequence aligner. Recently, the focus of his lab has shifted towards integrating AI into the de novo assembly process and innovating AI models to make RNA druggable.

In the initial decade of his career, Dr Šikić was engaged in various industry projects related to computer and mobile networks. He is an accomplished entrepreneur, having founded several ventures, including a hedge fund.

This talk is part of the Artificial Intelligence Research Group Talks (Computer Laboratory) series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Artificial Intelligence Research Group Talks (Computer Laboratory)
• Cambridge Centre for Data-Driven Discovery (C2D3)
• Cambridge Forum of Science and Humanities
• Cambridge Language Sciences
• Cambridge talks
• Chris Davis' list
• Department of Computer Science and Technology talks and seminars
• Guy Emerson's list
• Hanchen DaDaDash
• Interested Talks
• Lecture Theatre 2, Computer Laboratory, William Gates Building
• School of Technology
• Speech Seminars
• Trust & Technology Initiative - interesting events
• bld31
• ndk22's list
• ob366-ai4er
• rp587
• yk373's list
• yk449

Note that ex-directory lists are not shown.