Protein allostery as an illustration of an ensemble approach towards understanding biological function

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• Andrea Liu (University of Pennsylvania)
• Friday 08 December 2023, 11:30-12:00
• Seminar Room 1, Newton Institute.

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SPLW05 - Non-equilibrium explorations on the physics of life : remembering the biological physics of Tom McLeish

We know from statistical physics that we need ensembles in order to extract microscopic understanding of collective phenomena. We have designed central-force spring networks to have a function inspired by protein allostery, in which a strain applied locally gives rise to a comparable local strain at a distant location. By analyzing an ensemble of networks designed to have the similar response, we find that the response is of a topological nature and can be characterized using persistent homology. Our analysis shows that allostery does not arise from discrete mechanisms but rather a continuum. Application of the persistent homology analysis to real proteins shows similar results.

This talk is part of the Isaac Newton Institute Seminar Series series.

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