Mechanosensing in the pancreatic cancer microenvironment

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• Laura Machesky (CRUK Beaton Institute, University of Glasgow)
• Monday 16 October 2023, 13:00-14:00
• Seminar Room 2, Newton Institute.

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SPL - New statistical physics in living matter: non equilibrium states under adaptive control

Pancreatic cancer is highly metastatic, with a 5-year survival rate of less than 10%.  Tumours are hallmarked by accumulation of highly fibrotic extracellular matrix, which correlates with poor prognosis and spread to organs such as liver, lung and peritoneal cavity.  Our aim is to understand the molecular connections between force sensing and aggressiveness of tumour cells.  We recently discovered a connection between mechanosensing, invasive migration and metabolic supply/demand in pancreatic cancer cells.  I will discuss our model for how cells align their cytoskeletal polarity with their metabolic machinery to meet the high demands of the cancer microenvironment.  If we can better model and understand this alignment, we can hope to find new ways to target the aggressiveness and spread of pancreatic cancer.   

This talk is part of the Isaac Newton Institute Seminar Series series.

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