Non-equilibrium phase transition in the nucleus of a living cell

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• Alexander Grosberg (New York University)
• Friday 13 October 2023, 15:40-16:20
• Seminar Room 1, Newton Institute.

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SPLW03 - Biological condensates: cellular mechanisms governed by phase transitions

Nucleus of a living cell houses a cell genome – a polymer called chromatin, which is a functional form of DNA .  It is very long, e.g., 2 meters long for every human cell.  Nucleus is also an arena of incessant energy-driven activity.  Experiments show that chromatin undergoes large, several micron, scale motions sustained over long times of order seconds.  In the talk, after reviewing the phenomenology, I will show how these flows may arise due to a phase transition in which chromatin-driving motors, such as RNA polymerase, form a polar (“ferromagnetic”) order. 

This talk is part of the Isaac Newton Institute Seminar Series series.

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