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Open problem/Discussion: Dictyostelium swarms: an example of active biological fluids?

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MMV - Mathematics of movement: an interdisciplinary approach to mutual challenges in animal ecology and cell biology

Dictyostelium amoebae are widely studied for their collective cell migration. State-of-the-art imaging reveals the complex spatio-temporal evolution of Dictyostelium cell swarms as they move along self-generated bacterial gradients. Interestingly, as the swarms move collectively, they periodically shed droplets of cells at the rear. By representing the cell swarm as a thin active droplet, we build a continuum model that can replicate the experimentally observed shedding dynamics. However, how does the active and fluid-like nature of the swarm emerge as a result of interactions amongst Dictyostelium cells?

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