University of Cambridge > > SciSoc – Cambridge University Scientific Society > How Best to Explore Chemical Space for Bioactive Molecular Discovery

How Best to Explore Chemical Space for Bioactive Molecular Discovery

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Drishtant Chakraborty.

The discovery of bioactive small molecules is a challenge that is central to both drug discovery and chemical biology. However, given that there may be >10^30 drug-like small molecules, how can we discover molecules with specific biological functions? The challenge is compounded by chemists’ highly uneven and unsystematic historic exploration of chemical space: the reliance of a small toolkit of reactions means that the known chemistry ‘universe’ is dominated by a small number of structural classes that are found in many different molecules.

First, I will explain how we can draw inspiration directly from the structures of nature’s bioactive small molecules: natural products. Second, I will explain how we have been inspired by how biosynthetic pathways emerge in the first place to develop our function-directed discovery approach: activity-directed synthesis. Finally, I will discuss the prospects for realising fully autonomous molecular discovery: this would require chemical design to be algorithmically-driven and all experimental tasks are fully automated and integrated.

This talk is part of the SciSoc – Cambridge University Scientific Society series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.


© 2006-2024, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity