Using model active tissues containing active chromatin to test multi-scale hypotheses in cellular collectives

Add to your list(s) Download to your calendar using vCal

• Jennifer Schwarz (Syracuse University)
• Wednesday 06 September 2023, 11:50-12:20
• Seminar Room 1, Newton Institute.

If you have a question about this talk, please contact nobody.

SPLW02 - Active mechanics, from single cells to cell layers, tissues and development

Organoids are in vitro cellular collectives that give us a window into morphogenesis.  In such collectives, the DNA scale is key to determining organoid structure, be it brain, kidney, or heart. Using a three-dimensional vertex model as a cellular-based model for an organoid with embedded model cell nuclei, we begin to address this hierarchy-of-scales phenomenon by focusing on the simpler chromatin-to-tissue scale organization puzzle. We show that such a minimal, multi-scale model can be used test a hypothesis regarding a mechanism by which the size of human-derived brain organoids differs from the size of chimpanzee-derived brain organoids, for example.  

This talk is part of the Isaac Newton Institute Seminar Series series.

This talk is included in these lists:

• All CMS events
• Featured lists
• INI info aggregator
• Isaac Newton Institute Seminar Series
• School of Physical Sciences
• Seminar Room 1, Newton Institute
• bld31

Note that ex-directory lists are not shown.