From isolated, deformable cells to living tissues: a unified description

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• Massimo Pica Ciamarra (Nanyang Technological University)
• Friday 08 September 2023, 11:30-12:00
• Seminar Room 1, Newton Institute.

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SPLW02 - Active mechanics, from single cells to cell layers, tissues and development

We introduce a bottom-up mechanical model to relate tissues' dynamical and mechanical properties to intercellular and subcellular mechanical processes, which we describe in unprecedented detail. Our novel computational model overcomes the limitations of Vertex/Voronoi models, centroid models and phase fields one. It provides a unified description of motile isolated deformable cells, their interaction and aggregation into confluent tissues, the lamellipodium-mediated dynamics and mechanotransduction. In this talk, I briefly introduce our novel model and use it to examine how mechanotransduction enables tissues to flow confluently when under tension.  

This talk is part of the Isaac Newton Institute Seminar Series series.

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