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Modelling active cell intercalations in Drosophila axis extension

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SPLW02 - Active mechanics, from single cells to cell layers, tissues and development

In this talk I will describe some of our modelling work to understand the dynamics and mechanics of active cell intercalations underlying germband extension in the Drosophila embryo, progressing from a vertex model featuring locally patterned cell-cell interaction forces to a more detailed ‘apposed cortex adhesion’ model. I will also discuss some of our work to implement a variety of ‘cell-based’ modelling approaches in a consistent computational framework.

This talk is part of the Isaac Newton Institute Seminar Series series.

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