Encoding and Decoding of Molecular Information in Distributed Cellular Systems with Feedback Control

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• Madan Rao (National Centre for Biological Sciences)
• Monday 04 September 2023, 15:40-16:20
• Seminar Room 1, Newton Institute.

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SPLW02 - Active mechanics, from single cells to cell layers, tissues and development

It is often useful to think about Cells and Tissues as Distributed Computing Systems with Feedback Control, especially in the context of the processing of noisy molecular information. I will illustrate this in two parts. In the first, I will talk about cellular compartmentalisation and receptor promiscuity as a strategy for accurate inference of position during Morphogenesis. In the second, I will discuss the synthesis of a complex Glycan code in the Golgi cisternae, and how cisternal number and enzyme promiscuity achieves the target distribution with high fidelity.

This talk is part of the Isaac Newton Institute Seminar Series series.

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