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Emergence of flows and tridimensional structures in active cell monolayers

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SPLW02 - Active mechanics, from single cells to cell layers, tissues and development

In embryonic development or tumor evolution, cells collectively migrate within complex microenvironments set by the surrounding tissues and the structure of the extracellular matrix. Therefore, the characteristic length scales involved range from hundreds of nanometers to hundreds of microns. These conditions can be reproduced in vitro by exposing cell monolayers to well-controlled microfabricated structures. I’ll discuss the impact of these characteristic length scales on the collective flows that are generated by cell activity, and present experiments where the cells themselves shape their microenvironment in such a way as to retain the memory of their 2D architecture as they form multilayers.

This talk is part of the Isaac Newton Institute Seminar Series series.

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