Multiscale synthesis of coupled dynamic gene expression during neural development

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• Professor Nancy Papolopulu, School of Medical Sciences, University of Manchester
• Thursday 23 November 2023, 13:00-14:00
• Biffen Lecture theatre and Zoom.

If you have a question about this talk, please contact Caroline Newnham.

Host - Ben Steventon

In recent years, our understanding of how cells transition from proliferation to differentiation has been transformed by the application of single cell quantitative approaches and live imaging. Such approaches have led to by discovery of short-time scale protein expression oscillations which are exemplified by the expression of HES /Her transcription factors in neural progenitors. In my talk, I show how dynamic single cell live imaging of knocked-in reporters can be combined with mathematical modelling to analyse ultradian oscillations during vertebrate neural development, taking into consideration heterogeneity and stochasticity. I will show how single cell oscillations undergo multiscale synthesis when cells interact in a tissue environment and how the emergent pattern may control the rate and spacing of differentiation.

This talk is part of the Genetics Seminar series.

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