University of Cambridge > > Genetics Seminar  > Challenges and solutions in identifying the genes responsible for local adaptation

Challenges and solutions in identifying the genes responsible for local adaptation

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  • UserProfessor Michael Whitlock from Department of Zoology, University of British Columbia, Vancouver
  • ClockThursday 05 October 2023, 14:00-15:00
  • HouseBiffen Lecture theatre and Zoom.

If you have a question about this talk, please contact Caroline Newnham.

Host - John Welch

With the advent of increasingly accessible population genomic information from a wider number of species, “genome scans” to detect the genetic basis of local adaptation have become more common. The genome scans tend to look for unusually high among-population differentiation (FST outlier approaches) or correlations between local allele frequency and a relevant environmental variable (Genome-Environment Associations, GEA ). I will discuss some common challenges to genome scan approaches, such as the effect of recombination rate variation, the difficulty of separating local adaptation and ongoing global adaptation, and subtle challenges caused by the details of population structure. I also present a new method of GEA , called Weighted Z analysis or WZA , which seems to outperform alternate methods.

This talk is part of the Genetics Seminar series.

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