University of Cambridge > > Isaac Newton Institute Seminar Series > A Prompt Gamma-Ray Detection System for 3D Range Verification in Proton Beam Therapy

A Prompt Gamma-Ray Detection System for 3D Range Verification in Proton Beam Therapy

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RNTW03 - New tomographic methods using particles

There are a number of key uncertainties associated with proton beam therapy compared to photon therapy. Mitigation of these uncertainties is attempted through robust optimisation at the treatment planning stage or the addition of margins. Anatomical changes, however, occurring over a fractionated course of treatment are difficult to predict and account for. Such anatomical changes can have serious clinical consequences when treating with protons, namely the delivery of high dose to healthy tissue. To help detect these anatomical changes and validate the dose delivered, in a non-invasive way without extending the overall treatment time, a new gamma-ray detection system is being developed. The system aims to determine the proton beam range in all three dimensions, for pencil-beam scanning systems. The range is determined through the reconstruction of the origin of prompt gamma (PG) rays emitted from nuclear de-excitations following proton bombardment. The prototype system is comprised of 16 symmetrically-spaced LaBr3(Ce) detectors. The position reconstruction capability of the detector system was initially investigated by means of Geant4 simulations. To determine the PG-ray emission positions in 3D, the information recorded by each detector is fed into a novel in-house developed reconstruction algorithm. The Geant4 simulated data show that, with realistic detector characteristics, the reconstruction algorithm is capable of determining an isotropic point gamma-ray source with an uncertainty of less than 1 mm in 3D space. The reconstruction algorithm has been empirically validated and an in-silico investigation has now begun to ascertain the system performance with a spot scanning proton beam therapy system. The simulation results to-date along with the empirical validated will be shown and discussed.

This talk is part of the Isaac Newton Institute Seminar Series series.

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