Mitochondrial vesicles in immunology and evolution

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• Professor Heidi McBride from McGill University, Department of Neurology and Neurosurgery, Montreal, Quebec
• Thursday 26 January 2023, 14:00-15:00
• Zoom meeting.

If you have a question about this talk, please contact Caroline Newnham.

Host - Hansong Ma

Mitochondria are the evolutionary daughter of alpha-proteobacteria and their incorporation into ancient Archae over 2B years ago marked the beginning of eukaryogenesis. One of the common remaining features between mitochondria and their alpha-bacterial ancestors is the capacity to shed vesicles, processes with a broad range of physiological functions in both bacteria and mammalian cells. We have identified critical roles for mitochondrial derived vesicles (MDVs) in quality control pathways that traffic complexes to the late endosome/lysosome for degradation. We have also shown that MDVs are triggered during infection where they bridge the innate to adaptive immune signaling pathways, processes regulated by Parkinsons related proteins. MDV transport to peroxisomes is also essential in peroxisomal biogenesis pathways. I will discuss our recent findings showing a new pathway of pyroptotic cell death where MDV transport plays a central role, and our elaboration of further functional links to multiple Parkinsons disease related proteins. The implications of MDVs as highly conserved processes in evolution will also be highlighted throughout the discussion.

This talk is part of the Genetics Seminar series.

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