A systems approach to recovery of function

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• Cornelius Weiller Department of Neurology, Freiburg University, Freiburg, Germany
• Thursday 02 April 2009, 11:45-12:30
• Cripps Court, Magdalene College.

If you have a question about this talk, please contact Anna Di Pietro.

Brain’s functions are mainly organised in distributed, segregated and overlapping networks, comprising of nodes and interconnections. The functional properties of an area are determined by its connections. The various areas are not independent from each other. Their respective functions can only be understood in relation to the other parts of the network. Reorganisation due to lesions or intervention mainly takes place within the framework of these networks. The effects of lesions, dysfunction and stimulation or intervention depend on the pre- existing individual network architecture and the site and type of intervention. We use a new application of probalistic fibre tracking on DTI data to describe the anatomical course of connections between fMRI hot spots (as network nodes) in combination with measurements of effective connectivity with partial directed correlations to determine functionally defined brain networks in the domains of motor, language and attention. Application to fMRI data of stroke patients with hemiplegia, aphasia or neglect identifies “critical lesions” and tries to predict changes in reorganisation after stroke.

This talk is part of the Spring School 2009 - "Regeneration and Plasticity of Neural Circuits" series.

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