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Functional imaging of cortical connectivity in normal brain and neurodegenerative disease

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  • UserJames Rowe Cambridge University Centre for Brain Repair, University of Cambridge, Cambridge, UK
  • ClockWednesday 01 April 2009, 15:15-16:00
  • HouseCripps Court, Magdalene College.

If you have a question about this talk, please contact Anna Di Pietro.

Neurons and regional neuronal populations do not work in isolation. Rather, they are part of integrated neuronal networks, including both local and widely distributed networks. If one wishes to understand the complex effects of aging, focal lesions or neurodegeneration on brain function, one needs to include an assessment of the changes of connectivity within brain networks. A variety of methods are now readily available to characterise network connectivity based on magnetic resonance imaging data. The applications of several connectivity methods to analyse fMRI data will be illustrated. These include psychophysiological interactions, structural equation modelling and dynamic causal modelling. We will see how these methods give a richer understanding of the consequences of stroke, focal lesions, aging and Parkinson’s disease: an understanding that could not have been achieved from behavioural data or standard imaging methods. The changes in connectivity will be cautiously interpreted in terms of neuroplasticity, and related to assessment of novel strategies for restorative neurology.

This talk is part of the Spring School 2009 - "Regeneration and Plasticity of Neural Circuits" series.

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