Exploring host-tumour metabolic interactions using Drosophila

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• Dr Susumu Hirabayashi, MRC London Institute of Medical Sciences, Imperial College London
• Thursday 03 March 2022, 14:00-15:00
• Zoom meeting.

If you have a question about this talk, please contact Caroline Newnham.

Host - Chaitanya Dingare

Cancer is increasingly viewed as a systemic disease associated with a range of host metabolic changes including obesity, insulin resistance, and cachexia/muscle wasting syndrome, each of which alters the host metabolic and nutritional environment. Cancer cells actively acquire nutrients from the extracellular space to support their growth, but how cancer cells sense and respond to changes in systemic nutrient availability remains incompletely understood. We leverage the fruit fly Drosophila melanogaster as a model system to explore host-tumour metabolic and nutritional interactions. In this seminar, I present how our Drosophila studies have started reveal mechanisms by which tumours sense and exploit extracellular nutrients in the context of both obesity and systemic muscle wasting. I also demonstrate how tumours with different genetic alterations respond differently to obesity.

This talk is part of the Genetics Seminar series.

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