Decoding and Recoding the Opposing Roles of Interferon and Pattern Recognition Receptor Signaling in Cancer Immunotherapy

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• Andy J. Minn, MD, PhD, Abramson Family Cancer Research Institute at the University of Pennsylvania
• Thursday 16 December 2021, 13:00-14:00
• Zoom.

If you have a question about this talk, please contact Kate Davenport.

Please join via: https://zoom.us/j/92761420222?pwd=N3lHdmhIQk4zWExQeWJkN3QxV1Mvdz09 Meeting ID: 927 6142 0222 Passcode: 237565

Interferon (IFN) and pattern recognition receptor (PRR) signaling are important for immune activation and the effectiveness of cancer immunotherapies. However, these pathways can also have inhibitory roles due to entwined negative feedback mechanisms that can be exploited by tumors often after chronic stimulation. I will discuss our findings on how these opposing roles are regulated in cancer, how they can contribute to immunotherapy resistance, and approaches we are pursuing to mitigate the inhibitory effects of IFN /PRR signaling.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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