Advanced polarized light microscopy for mapping molecular orientation

Add to your list(s) Download to your calendar using vCal

• Prof Rudolf Oldenbourg, Marine Biological Laboratory, MA
• Tuesday 24 September 2019, 09:30-11:00
• Auditorium, Microsoft Research Ltd, 21 Station Road, Cambridge, CB1 2FB.

If you have a question about this talk, please contact Microsoft Research Cambridge Talks Admins.

 Please note, this event may be recorded. Microsoft will own the copyright of any recording and reserves the right to distribute it as required

Polarization is a basic property of light, but the human eye is not sensitive to it. Therefore, we don’t have an intuitive understanding of polarization-dependent phenomena. However, polarized light plays an important role in nature, and polarization microscopy can be used to understand molecular order in living cells, tissues, and whole organisms. The talk will describe a polarized light microscope, developed at the Marine Biological Laboratory (MBL) in Massachusetts, called the LC-PolScope. This instrument measures the orientation of molecules at every resolved specimen point simultaneously. In addition to birefringence and diattenuation, it can also map the polarized fluorescence of fluorophores used to label structures like cell membranes and filaments. Recently, these techniques have been extended to multi-view microscopes. With a single-view microscope, measuring the inclination angles of the optical axes of bonds, particles, and fluorophores with respect to the focal plane remains a challenge. Multi-view microscopes record images along several viewing directions, thereby enabling unambiguous measurement of the three-dimensional orientation of molecules and their aggregates

This talk is part of the Microsoft Research Cambridge, public talks series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Auditorium, Microsoft Research Ltd, 21 Station Road, Cambridge, CB1 2FB
• Cambridge Centre for Data-Driven Discovery (C2D3)
• Cambridge talks
• Chris Davis' list
• Guy Emerson's list
• Interested Talks
• Microsoft Research Cambridge, public talks
• Optics for the Cloud
• PMRFPS's
• School of Technology
• Trust & Technology Initiative - interesting events
• bld31
• ndk22's list
• ob366-ai4er
• personal list
• rp587

Note that ex-directory lists are not shown.