Centrosome amplification and cancer: reaching out

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• Dr Susana Godinho, Barts Cancer Institute, University of London
• Thursday 14 November 2019, 14:00-15:00
• Biffen Lecture Theatre, Department of Genetics, Downing Site.

If you have a question about this talk, please contact Caroline Newnham.

Hosts: David Glover & Paula Coelho

The centrosome is the main microtubule-organising centre in animal cells; important to assemble a bipolar mitotic spindle ensuring proper chromosome segregation and genomic stability. Centrosomal abnormalities, in particular centrosome amplification, are recurrent features of human tumours. Enforced centrosome amplification in vivo plays a role in tumour initiation and progression. However, centrosome amplification occurs only in a subset of cancer cells and thus, partly due to this heterogeneity, the contribution of centrosome amplification to tumours in unknown. We recently demonstrated that supernumerary centrosomes induce a paracrine-signalling axis via the secretion of proteins, which leads to non-cell autonomous invasion. This extra centrosomes-associated secretory phenotype (ECASP) is a consequence of a stress response caused by increased reactive oxygen species (ROS) in these cells. Furthermore, increased ROS not only drives secretion of pro-invasive factors, but also of small extracellular vesicles that change fibroblasts. We are now characterising this diverse secretory phenotype and its impact not only in cancer cells but in the surrounding microenvironment. The discovery that cells with extra centrosomes can manipulate the surrounding cells highlights unforeseen and far-reaching consequences of these abnormalities in cancer.

This talk is part of the Genetics Seminar series.

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