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Visualising Genome Folding Dynamics in Mammalian Cells - Theory and Experiments

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If you have a question about this talk, please contact Dr. Adrien Hallou.

Reading the genome is one thing, finding out how it functions is something else altogether. The three-dimensional organisation of the genome is one of the great marvels of physical biology. To fit inside tiny (6 μm) nuclei, the metre-long DNA folds in a way that avoids entanglement and maintains exquisite control over the accessibility of the information it carries. Genome folding is intimately linked to gene function regulation. However, how the genome is organized in space and how this organization influences its function remains unclear. In this talk, we will describe advances in multiscale computational modelling and in experimental approaches such as single-cell Hi-C and single-molecule imaging that allow us for the first time to visualise the dynamics of the genome.

This talk is part of the Theory of Living Matter Group series.

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