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Hacking the gene expression machinery for genome defense

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If you have a question about this talk, please contact Caroline Newnham.

Host: Felipe Karam Teixeira

There is an ongoing arms race between mobile genetic elements such as transposons and host genome defense systems. Both, prokaryotes and eukaryotes rely on small RNA pathways for the sequences specific silencing of transposons and other invading nucleic acids: CRISPR /Cas systems in bacteria and RNA interference pathways in plants, fungi, and animals. I will give a conceptual overview of the molecular logic of the Piwi/piRNA pathway, the major transposon silencing system in the animal germline. The focus of my talk will be on the intersection of the piRNA pathway with heterochromatin biology, and how evolution found ways to bypass the canonical ways of gene expression.

This talk is part of the Genetics Seminar series.

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