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University of Cambridge > Talks.cam > Isaac Newton Institute Seminar Series > MSG Design of Experiments Seminar Series: Simulation-based Bayesian experimental design for computationally intensive models

## MSG Design of Experiments Seminar Series: Simulation-based Bayesian experimental design for computationally intensive modelsAdd to your list(s) Download to your calendar using vCal - Xun Huan (Sandia National Laboratories; University of Michigan)
- Wednesday 20 June 2018, 14:55-15:45
- Seminar Room 1, Newton Institute.
If you have a question about this talk, please contact INI IT. UNQ - Uncertainty quantification for complex systems: theory and methodologies Selecting and performing experiments that produce the most useful data is extremely valuable in engineering and science applications where experiments are costly and resources are limited. Simulation-based experimental design thus provides a rigorous mathematical framework to systematically quantify and maximize the value of experiments while leveraging the existing knowledge and predictive capability of an available model. We are particularly interested in design settings that accommodate nonlinear and computationally intensive models, such as those governed by ordinary and partial differential equations. Employing principles from Bayesian statistics to characterize and quantify uncertainty, we seek experiments that maximize the expected information gain. Computing these optimal designs using conventional approaches, however, is generally intractable. Major challenges include high dimensional parameter spaces, expensive model simulations, and numerical approximation and optimization of the expected information gain. We thus describe practical numerical methods to help overcome these obstacles, including global sensitivity analysis, surrogate modeling via polynomial chaos, and stochastic optimization. The overall methodology is demonstrated through the design of combustion experiments for optimal learning of chemical rate parameters, and of configurations for a supersonic jet engine to obtain measurements most informative on turbulent flow parameters. This talk is part of the Isaac Newton Institute Seminar Series series. ## This talk is included in these lists:- All CMS events
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