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A stochastic story of two receptors and two ligands

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SDBW03 - Advances in numerical and analytic approaches for the study of non-spatial stochastic dynamical systems in molecular biology

In this talk, I will introduce the role of the co-receptors CD28 and CTLA -4 in the immune system. Both CD28 and CTLA -4 molecules are expressed on the membrane of T cells and can bind CD80 and CD86 ligand molecules, expressed on the membrane of antigen presenting cells. Classical immunology has identified CD28 co-receptor as enhancing the signal received by T cells from their T cell receptors (TCRs), and CTLA -4 as suppressing TCR signals. New experimental work is supporting a different role for the CTLA -4 molecule. In this talk, I will describe work in progress by our group, to model as  a multi-variate stochastic process the system of two receptors and two ligands. 

This talk is part of the Isaac Newton Institute Seminar Series series.

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