The structure and logic of axis extension in Drosophila

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• Blanchard, G (University of Cambridge)
• Thursday 08 October 2015, 11:00-12:30
• Seminar Room 2, Newton Institute Gatehouse.

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Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation

Convergence and extension movements are evolutionarily conserved morphogenetic behaviours that elongate tissues in many contexts in animal embryogenesis and organogenesis. Drosophila germ-band extension is a well-studied example that deforms the germ-band epithelium, a thin monolayer of cells tesselating the surface of the ellipsoidal embryo. Extension is driven by the combination of two temporally coordinated mechanisms. A pull from the posterior of the embryo drives extension of the tissue towards the posterior. Meanwhile, a planar polarised distribution of actin and Myosin II motors drives active cell rearrangements within the tissue, driving convergence in the dorso-ventral axis.

This talk is part of the Isaac Newton Institute Seminar Series series.

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