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Designs for dose-escalation trials

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Design and Analysis of Experiments

For First-in-Human trials of a new drug, healthy volunteers are recruited in cohorts. For safety reasons, only the lowest dose and placebo may be used in the first cohort, and no new planned dose may be used until the one immediately below has been used in a previous cohort. How should doses be allocated to cohorts?

This talk is part of the Isaac Newton Institute Seminar Series series.

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