COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring. |

University of Cambridge > Talks.cam > Isaac Newton Institute Seminar Series > Adaptive dose-finding with power control

## Adaptive dose-finding with power controlAdd to your list(s) Download to your calendar using vCal - Miller, F (Stockholm University)
- Monday 06 July 2015, 11:15-12:00
- Seminar Room 1, Newton Institute.
If you have a question about this talk, please contact webseminars. Design and Analysis of Experiments A main objective in dose-finding trials besides the characterisation of dose-response relationship is often to prove that the drug has effect. The sample size calculation prior to the trial aims to control the power for this effect proof. In most cases however, there is great uncertainty concerning the anticipated effect of the drug during planning. Sample size re-estimation based on an unblinded interim effect estimate has been used in this situation. In practice, this re-estimation can have drawbacks as sample size becomes variable which makes planning and funding complicated. Further it introduces the risk that people start to speculate about the effect once the re-estimated sample size is communicated. In this talk, we will investigate a design which avoids this problem but controls the power for the effect proof in an adaptive way. We discuss methods for proper statistical inference for the described design. This talk is part of the Isaac Newton Institute Seminar Series series. ## This talk is included in these lists:- All CMS events
- Featured lists
- INI info aggregator
- Isaac Newton Institute Seminar Series
- School of Physical Sciences
- Seminar Room 1, Newton Institute
Note that ex-directory lists are not shown. |
## Other listsCambridge Drosophila Seminar Series Arcsoc Dutch CU Native Spirit Society## Other talksDispersive Quantization of Linear and Nonlinear Waves Eukaryotic cell division and its origins What has Engineering Design to say about Healthcare Improvement? Cambridge-Lausanne Workshop 2018 - Day 2 Laser Printed Organic Electronics Seminar – The Cambridge Sustainable Food Hub |