![]() |
COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring. | ![]() |
University of Cambridge > Talks.cam > Computer Laboratory Wednesday Seminars > Cellular Systems Biology of Chromosome Dynamics
![]() Cellular Systems Biology of Chromosome DynamicsAdd to your list(s) Download to your calendar using vCal
If you have a question about this talk, please contact David Greaves. The questions of how genes are regulated remains fundamental even after many decades of intense study. Rather than just studying the linear, one-dimensional sequence of DNA to inform us about regulatory mechanisms, we can now investigate the complex 3-dimensional organisation of whole genomes. It has become clear that this organisation is non-random and highly dynamic. To address new questions in genome architecture, we are taking a systems biology approach, combining the bioinformatic determination of chromatin states with quantitative experiments and dynamic, stochastic models of whole genome organisation. These include polymer models of genome structure and particle-based simulations of protein movements. Comparing these results with our experimental data, this has led us to understand how biophysical properties of the chromatin fibre lead to significant and biologically relevant self-organisation of the genome. This talk is part of the Computer Laboratory Wednesday Seminars series. This talk is included in these lists:
Note that ex-directory lists are not shown. |
Other listsCreative Research at Museum of Archaeology & Anthropology Sainsbury Laboratory Seminars Cavendish Graduate Students' Conference 2009Other talksProtean geographies: Plants, politics and postcolonialism in South Africa THE MATHEMATICAL MAGIC OF MIXED REALITY C++ and the Standard Library Biosensor Technologies (Biacore SPR, Switchsense, Octet) Beating your final boss battle, or presenting with confidence and style (easy mode) Don't be Leeroy Jenkins – or how to manage your research data without getting your whole project wiped out |