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Genomics of transcription factor redundancy

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Many families of transcription factor recognise very similar binding motifs and, in some cases, are co-expressed in the same cells at the same time during development. We have been studying the Sox family in Drosophila, which show highly conserved nervous system expression and a very high degree of functional redundancy. We will examine activity and binding in wild type and mutant conditions as well as using evolutionary analysis to look at conserved and diverged activities of the Sox family.

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