University of Cambridge > Talks.cam > Isaac Newton Institute Seminar Series > A continuum model of epithelial spreading

A continuum model of epithelial spreading

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Mustapha Amrani.

Mathematical Modelling and Analysis of Complex Fluids and Active Media in Evolving Domains

We present a continuum model of unconstrained epithelial spreading. The tissue is described as a polarizable and chemo-mechanically interacting layer with neo-Hookean elasticity. Our model reproduces the spontaneous formation of finger-like protrusions commonly observed in experiment. Statistics of velocity orientation obtained from numerical simulation show strong alignment in the fingers opposed to an isotropic distribution in the bulk, as has been measured by Reffay et al. (Reffay et al., Biophysical Journal, 2011). The results faithfully reproduce faster relative advance of cells close to the leading edge of the tissue, as well as spatial velocity correlations and stress accumulation within the tissue, which proceeds in form of a “mechanical wave”, traveling from the wound edge inwards (cf. Serra-Picamal et al., Nature Physics, 2012).

M H Koepf, L M Pismen: A continuum model of epithelial spreading (2013) submitted

M H Koepf, L M Pismen: Non-equilibrium patterns in polarizable active layers (2013) submitted

Co-author: Leonid M. Pismen (Department of Chemical Engineering, Technion – Israel Institute of Technology, 32000 Haifa, Israel)

This talk is part of the Isaac Newton Institute Seminar Series series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

 

© 2006-2017 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity