|COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring.|
Computer simulations of knotted DNA and proteins
If you have a question about this talk, please contact Mustapha Amrani.
Topological Dynamics in the Physical and Biological Sciences
When mature bacteriophages such as P2 or P4 are assembled in infected cells, a long linear DNA molecule is loaded into the phage capsid and arranges itself in a toroidal, nematic phase. Intriguingly, experiments show that the DNA is not only highly knotted, but also exhibits a rather uncommon knot spectrum. Observation that DNA molecules in bacteriophage capsids preferentially form torus knots provide a sensitive gauge to evaluate various models of DNA arrangement in phage heads. We demonstrate with computer simulations of a simple bead-spring model that an increasing chain stiffness not only leads to nematic ordering and a (somewhat counter-intuitive) increase of knottedness, it is also the decisive factor in promoting formation of DNA torus knots in phage capsids. In the second part of my presentation I will review recent and not so recent advances in the understanding and modelling of protein knots.
This talk is part of the Isaac Newton Institute Seminar Series series.
This talk is included in these lists:
Note that ex-directory lists are not shown.
Other listsepiSTEMe dissemination event Vilamovicean Audio and Music Processing (AMP) Reading Group
Other talks"Technologies for learning and well-being" Title TBC. Subject area: spinal cord injury The organelles and traffic machinery of the late endocytic pathway Monopoles, instantons and polytopes Building abstractions in Language Development A role for the e-portfolio in educating the professional musician (not the music teacher)