|COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring.|
The role of topological constraints on condensed polymers and DNA in human cells
If you have a question about this talk, please contact Mustapha Amrani.
Topological Dynamics in the Physical and Biological Sciences
Human DNA is two meters long and is folded into a structure that fits in a cell nucleus of just 5 microns in diameter. Recently developed Hi-C technique provides comprehensive information about genome folding. Our analysis of Hi-C data provides and biophysical polymer modeling show that scaling observed in the data is consistent with non-equilibrium and unknotted polymer state the crumpled (fractal) globule. We demonstrate that the fractal globule emerges as a result of polymer collapse and has a short lifetime, rapidly mixing while remaining largely unknotted. Long-time dynamics of a condensed polymer reveals that spatial and topological equilibration happen at vastly different time scales and that topological constrains have little effect on relatively short and flexible chains.
This talk is part of the Isaac Newton Institute Seminar Series series.
This talk is included in these lists:
Note that ex-directory lists are not shown.
Other listsLucy Cavendish College 8th International Prader-Willi Syndrome Organisation conference Rasch Users Group
Other talksHydrodynamic description of the actin cortex Forming massive seed black holes by direct collapse "Using computational methods to aid our understanding of ionotropic glutamate receptors at the molecular level" 'The mitochondrial permeability transition pore: A mystery solved?' A rigid or elastic plate floating on the free surface of a viscous film: a coupled free boundary and fluid-structure interaction problem Hydrodynamic description of thin nematic films