COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring. |

University of Cambridge > Talks.cam > Isaac Newton Institute Seminar Series > Designs for mixed models with binary response

## Designs for mixed models with binary responseAdd to your list(s) Download to your calendar using vCal - Waite, T (Southampton)
- Tuesday 09 August 2011, 16:00-16:45
- Seminar Room 1, Newton Institute.
If you have a question about this talk, please contact Mustapha Amrani. Design and Analysis of Experiments For an experiment measuring a binary response, a generalized linear model such as the logistic or probit is typically used to model the data. However these models assume that the responses are independent. In blocked experiments, where responses in the same block are potentially correlated, it may be appropriate to include random effects in the predictor, thus producing a generalized linear mixed model (GLMM). Obtaining designs for such models is complicated by the fact that the information matrix, on which most optimality criteria are based, is computationally expensive to evaluate (indeed if one computes naively, the search for an optimal design is likely to take several months). When analyzing GLM Ms, it is common to use analytical approximations such as marginal quasi-likelihood (MQL) and penalized quasi-likelihood (PQL) in place of full maximum likelihood. In this talk, we consider the use of such computationally cheap approximations as surrogates for the true information matrix when producing designs. This reduces the computational burden substantially, and enables us to obtain designs within a much shorter time frame. However, other issues also need to be considered such as the accuracy of the approximations and the dependence of the optimal design on the unknown values of the parameters. In particular, we evaluate the effectiveness of designs found using these analytic approximations through comparison to designs that are found using a more computationally expensive numerical approximation to the likelihood. This talk is part of the Isaac Newton Institute Seminar Series series. ## This talk is included in these lists:- All CMS events
- Featured lists
- INI info aggregator
- Isaac Newton Institute Seminar Series
- School of Physical Sciences
- Seminar Room 1, Newton Institute
- bld31
Note that ex-directory lists are not shown. |
## Other listsCambridge University Entrepreneurs (CUE) Electron Microscopy Group Conferences Judge Business Club Financial Economcs Series## Other talksRevolution and Literature: Volodymyr Vynnychenko's Responses to the Ukrainian Revolution of 1918-1920 Designing Active Macroscopic Heat Engines Epigenetics: One Genome, Multiple Phenotypes Science Makers: multispectral imaging with Raspberry Pi Intravital Imaging – Applications and Image Analysis/ Information session on Borysiewicz Biomedical Sciences Fellowships Comparative perspectives on social inequalities in life and death: an interdisciplinary conference |