Revolutionizing Biosensing Technologies: Plug and Play Devices in Medical and Agricultural Diagnostics

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• Muhammad J. A. Shiddiky, Rural Health Research Institute (RHRI), Charles Sturt University, Orange NSW 2800
• Tuesday 24 October 2023, 17:00-18:00
• Lecture Theatre 2, Computer Laboratory, William Gates Building.

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Abstract

The availability of simple, rapid, and inexpensive methods, along with plug-and-play devices that can diagnose and treat diseases at their early stages on-site, has the potential to transform biomedical and agricultural disease diagnosis. This transformation would shift the current disease-centric system to a more personalized, predictive, and preventative model, focused on disease prevention and management. In addition to improving overall diagnosis and disease management strategies, the plug-and-play test would also be particularly valuable in remote locations, such as rural communities (i.e., Aboriginal and Torres Strait Islander people), military units, and remote farms and agricultural fields. Current diagnostic methods for biomedical and agricultural applications often require expensive materials and laborious procedures, as well as sophisticated instrumentation and facilities. As a result, they are not widely accessible in rural communities, developing countries, or other resource-poor settings.

The emergence of magnetic nanomaterials that function as both ‘dispersible capture agents’ and ‘nanoenzymes’ with peroxidase-like activity has been instrumental in the development of more affordable, on-site diagnostic methods and devices. In recent years, our team has developed several methods and devices utilizing a series of nano-architected magnetic nanomaterials, 3D printing technology, advanced engineering, and alternating current (AC)-induced fluid manipulation in purpose-built microfluidic devices. We have used these tools to achieve ‘plug-and-play’ analysis of many biomedical biomarkers, such as circulating cancer biomarkers like CTCs, exosomes, RNAs, cell-free DNA (cf-DNA), circulating tumor DNA (ct-DNA), agricultural biomarkers such as plant disease causative pathogens and their corresponding nucleic acid sequences, and global water-related disease (i.e., cryptosporidiosis, giardiasis) biomarkers. In this presentation, I will discuss some of these developments, highlighting the applications of a few new handheld devices in these areas.

Bio

Professor Shiddiky is a Distinguished Professor of Nanotechnology at the Rural Health Research Institute (RHRI) at Charles Sturt University (Orange Campus), NSW , Australia. He obtained his PhD in 2007 and subsequently held positions as a Postdoctoral Research Fellow at Monash University, an ARC DECRA Fellow at the University of Queensland, an NHMRC Career Development Fellow, and an Associate Professor at Griffith University. He is a global leader in the fields of analytical chemistry, sensor technology, and nanobiotechnology, specializing in developing biosensing methods and portable diagnostic devices for various biomedical and agricultural applications. He leads an ambitious research program at RHRI aimed at developing point-of-care/on-site diagnostic devices and technologies for early detection and management of diseases from concept through to commercialization. His work is highly translational and has resulted in multiple licensed IPs, several industrial collaborations, and commercial research contracts. Additionally, his research has laid the foundation for two global biotech start-up companies by providing critical background IPs. Prof Shiddiky has a career total of 180 publications, with over 9000 citations (h-index = 58). The average citation rate of his publications is 49+ citations per article. He serves as a member of the Editorial Board/Editorial Advisory Board in several top-quality journals, including Analytical Chemistry (ACS), Scientific Reports (Springer Nature), and Analyst (RSC)

This talk is part of the Foundation AI series.

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